Cape Breton-Canso-Antigonish is a federal electoral district in Nova Scotia, Canada, that has been represented in the House of Commons of Canada since 2004. Its population in 2021 was 71,380. It is the successor to Bras d'Or (later known as Bras d'Or-Cape Breton), which was represented in the House of Commons from 1997 to 2004.
The district includes eastern Guysborough County, and the western, southern and eastern coasts of Cape Breton Island. Communities include Glace Bay, Louisbourg, Inverness, Chéticamp, St. Peters, Port Hawkesbury, Mulgrave, Guysborough, Dominion, Canso and Antigonish.